{"id":1051,"date":"2017-05-19T10:14:12","date_gmt":"2017-05-19T02:14:12","guid":{"rendered":"https:\/\/www.klkoleo.com\/davoslife\/?p=1051"},"modified":"2018-02-02T15:13:49","modified_gmt":"2018-02-02T07:13:49","slug":"tocotrienols-are-playing-the-key-role-in-mitigating-ulcerative-colitis","status":"publish","type":"post","link":"https:\/\/www.klkoleo.com\/davoslife\/tocotrienols-are-playing-the-key-role-in-mitigating-ulcerative-colitis\/","title":{"rendered":"Tocotrienols are playing the key role in mitigating ulcerative colitis"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damaged colonic mucosa layer due to excessive inflammatory reactions and oxidative\u00a0<\/span><span class=\"s1\">stress. <\/span><span class=\"s1\">It is affecting millions of patients in mostly developed countries. Preventive measures, aiming to keep the disease in remission, are sought after for this incurable,\u00a0<\/span><span class=\"s1\">recurring autoimmune disease. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Tocotrienols (T3s), members of vitamin E family, possesses strong anti-oxidative and anti-inflammatory properties. This murine study aims to\u00a0<\/span><span class=\"s1\">examine the preventive use of <\/span><span class=\"s2\">T<\/span><span class=\"s1\">ocotrienol-rich fraction (TRF) in mitigating damages in the colon. Mice were pre-supplemented with TRF or alpha-tocopherol (\u03b1-TP) for a week<\/span> <span class=\"s1\">before acute UC was induced. Observable clinical manifestations and quality of stool were assessed; post-mortem histopathological and biomolecular analyses were done.<\/span> <span class=\"s1\">Results showed that there were improvements on clinical conditions in TRF-supplemented animals; these included less reduction in body weight, absence of faecal blood and<\/span> <span class=\"s1\">better stool quality. <\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Histopathological analysis showed more intact mucosa layer in these animals. Reduction in the level of nitric oxide and malondialdehyde in the colons of<\/span> <span class=\"s1\">TRF-supplemented animals indicated less oxidative local environment. TRF supplementation also reduced the levels of some pro-inflammatory cytokines and proteins,<\/span> <span class=\"s1\">including tumour necrosis factor-\u03b1 and myeloperoxidase. In contrast, \u03b1-TP supplementation did not demonstrate evident clinical and histopathological improvements.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><a href=\"https:\/\/www.klkoleo.com\/davoslife\/wp-content\/uploads\/2017\/05\/Tocotrienols-Are-Playing-The-Key-Role-In-Mitigating-Ulcerative-Colitis.pdf\">Download<\/a> the <\/span><span class=\"s2\">study<\/span> <span class=\"s2\">to learn more.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>KLK OLEO and Davos Life Science presented a poster about the health benefits of Tocotrienols supplementation on ulcerative colitis, a form of inflammatory bowel disease in Vitafoods Europe 2017.<\/p>\n","protected":false},"author":2,"featured_media":1070,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"journals-health-benefit":[],"journals-year":[],"news-events-year":[],"articles-year":[],"articles-health-benefit":[],"news-events-category":[],"class_list":["post-1051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-events"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/posts\/1051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/comments?post=1051"}],"version-history":[{"count":0,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/posts\/1051\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/media\/1070"}],"wp:attachment":[{"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/media?parent=1051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/categories?post=1051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/tags?post=1051"},{"taxonomy":"journals-health-benefit","embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/journals-health-benefit?post=1051"},{"taxonomy":"journals-year","embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/journals-year?post=1051"},{"taxonomy":"news-events-year","embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/news-events-year?post=1051"},{"taxonomy":"articles-year","embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/articles-year?post=1051"},{"taxonomy":"articles-health-benefit","embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/articles-health-benefit?post=1051"},{"taxonomy":"news-events-category","embeddable":true,"href":"https:\/\/www.klkoleo.com\/davoslife\/wp-json\/wp\/v2\/news-events-category?post=1051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}