Background: Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic ap-proaches are effective yet they are not without adverse ef-fects. Vitamin E has great potential as an adjunctive treat-ment for AD owing to its antioxidant and anti-inflammatory bioactivities.
Summary: This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a con-tact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD pa-tients. Future research on the distinct effects of different vi-tamin E isoforms as well as their delivery system in skin dis-orders is needed.