Corporate News:

Singapore scientists show vitamin E tocotrienol inhibits stomach cancer cell growth and potentiates anti-cancer effects of stomach cancer drug in animal models

Results from a study conducted by scientists from the National University of Singapore (NUS) in collaboration with Davos Life Science showed that the administration of gamma-tocotrienol, the isoform of tocotrienol, a novel vitamin E constituent significantly suppressed the growth of stomach cancer cells in mice. Furthermore, results from the study which was recently published in the February 2012 peer-reviewed Clinical Cancer Research showed that the combination of gamma-tocotrienol and capecitabine, a chemotherapy drug commonly given to treat stomach cancer inhibited the activation of key cancer biomarkers such as NF-kB.

Study reports gamma-tocotrienol inhibits gastric cancer cell growth and potentiates anti-cancer effects of gastric cancer drug capecitabine in animal models

A recently published study in the February 2012 peer-reviewed Clinical Cancer Research reports that gamma-tocotrienol, an isoform of the vitamin E constituent tocotrienol, inhibits the growth of human gastric cancer cells in animal models and enhances the anti-cancer effects of capecitabine, a chemotherapy drug commonly used to treat colorectal cancer. Results from the study which was conducted by scientists from the National University of Singapore (NUS) in collaboration with Davos Life Science showed that the administration of gamma-tocotrienol alone significantly suppressed tumor growth in xenograft models of human gastric cancer in nude mice. Furthermore, results from the study showed that the combination of gamma-tocotrienol and capecitabine downregulated proliferation markers (Ki-67) and markers for microvessel density CD31. Finally, the administration of gamma-tocotrienol also inhibited the activation of NF-kB and suppressed NF-kB regulated expression of cancer biomarkers such as COX2, cyclin D1, Bcl-2, CXCR4, VEGF, and MMP-9.