Davos Life Science recently published its findings on how oral supplementation of Tocotrienols-rich fraction (TRF) – a palm oil extract – could alleviate the severity of ulcerative colitis in mice.
Ulcerative colitis is a form of inflammatory bowel disease (IBD) that could lead to continuous inflammation in the digestive tract.
In the study, the healthy mice were used to compare against the mice that were induced with ulcerative colitis using dextran sulfate sodium (DSS).
The DSS induced-ulcerative colitis mice were then grouped into four treatment groups: 1) control, 2) 150mg/kg/day of TRF, 3) 150mg/kg/day of alpha-tocopherol (αTP) – also a form of vitamin E, and 4) 75mg/kg/day of 5-aminosalicylic acid (5-ASA).
The results showed that mice treated with TRF had a lower disease activity index. The index is measured by the amount of body weight loss, stool consistency and bleeding. The higher the index, the higher the severity of ulcerative colitis.
Read full article published in the NutraIngredient.com
Source of Article: Journal of Nutrition Science and Vitaminology
Oral Supplementation of Tocotrienol-rich Fraction Alleviates Severity of Ulcerative Colitis in Mice